Can use DosBox, which is a DOS emulator that runs on Mac OS.
Download
Download from its official site. Choose the “Mac OS X” one. It is a dmg file, then can open the “DosBox” app inside the dmg file. Can also move it to Applications folder.
Mount the Drive on DOS
Mount the drive. On your Mac OS, create a folder for Doc. For example
mkdir -p ~/DosBox
Put the DOS programs in this folder.
Get into the DOS prompt of DosBox, run
mount c ~/DosBox
c:
Run the DOS program
Then you can cd into the program and run it.